Recurrent Pregnancy Loss: Why an Individualised Evaluation Matters
Investigating two or more consecutive miscarriages: genetic, anatomical, endocrine, and immunological factors.
Reviewed by Dr. Dileep Kumar H R, MBBS, DGO, DRM
October 2026 · Evidence-Based Healthcare
Experiencing recurrent pregnancy loss (RPL) is an agonizing ordeal. Couples often feel caught between grief and the fear of trying again.
Clinical guidelines define recurrent pregnancy loss as two or more failed pregnancies. An exhaustive, empathetic investigation is warranted rather than assuming bad luck.
Key diagnostic targets include: 1. Parental karyotyping to rule out balanced chromosomal translocations; 2. Uterine cavity assessment via 3D ultrasound or hysteroscopy for uterine septums, fibroids, or intrauterine adhesions; 3. Antiphospholipid Syndrome (APS) and thrombophilia screening; 4. Endocrine checks for subclinical hypothyroidism, diabetes, or luteal phase defect.
With targeted diagnosis and supportive early pregnancy care, over 70% of couples with recurrent loss achieve a healthy live birth.
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Frequently Asked Questions
Yes. A congenital uterine septum has poor vascularity, which can cause early embryonic implantation failure. It can be easily corrected with minimally invasive hysteroscopic metroplasty.